University of Florida
researchers have received a $900,000 grant from the National Institutes
of Health to study a new treatment for language problems that commonly
occur after a stroke.
Led by Bruce Crosson, Ph.D.,
a professor of clinical and health psychology at the UF College of
Public Health and Health Professions, the research team will investigate
the effectiveness of a new therapy for the language disorder known as
nonfluent aphasia. Patients with nonfluent aphasia have trouble finding
the right words to communicate their meaning, speaking in sentences or
saying more than one or two words without stopping.
About 750,000 Americans
experience a stroke annually, according to the National Stroke
Association.
"Approximately 25 percent of
strokes are associated with aphasia and only 21 percent of these
patients eventually recover normal language function," Crosson said.
"Thus, it is estimated that more than 1 million Americans experience
chronic aphasia that substantially limits their ability to work, affects
relationships with friends and family and degrades quality of life for
survivors."
Researchers will employ the
concept of neuroplasticity - the idea that the brain can be reorganized
so that other parts of the brain can take over lost functions. Because
the left side of the brain is responsible for language in right-handed
individuals, a stroke on the brain's left side can damage its language
production centers. In the UF study, investigators will attempt to shift
language production to the right side of the brain in patients with
stroke.
During the course of the
study participants will complete a series of verbal exercises. Patients
will be shown a series of pictures on a computer screen and will be
asked to name the object. In a later phase of the study, they will be
given a category, for example, "birds," and will be asked to name a
member of that category, such as "robin." Some participants will
initiate verbal exercises by pressing a button, and others will receive
prompts to initiate their exercises.
"The idea is to determine if
one method of initiating verbal responses is better than the other at
coaxing the brain to reorganize word production to its right side,"
Crosson said.
To measure changes in right
brain function, participants will undergo functional magnetic resonance
imaging scans before therapy begins, at the end of the treatment period
and three months after treatment is completed. The scans provide
researchers with a view of which parts of the brain are active during
speech.


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